AAA

GPR75拮抗剂；增加基础GPR75蛋白水平并抑制20-HETE诱导的PC3细胞中GPR75蛋白水平降低；降低5和10µM时20-HETE诱导的PC3细胞中EGFR、NF-κB和Akt的磷酸化以及细胞迁移；以每天10mg/kg的剂量降低Cyp1a1-Ren-2转基因大鼠恶性高血压模型中的收缩压、白蛋白尿、肾血管紧张素II水平和心脏肥大。A GPR75 antagonist; increases basal GPR75 protein levels and inhibits 20-HETE induced reductions in GPR75 protein levels in PC3 cells; reduces 20-HETE-induced phosphorylation of EGFR, NF-κB, and Akt in, and cell migration of, PC3 cells at 5 and 10 µM; reduces systolic blood pressure, albuminuria, renal angiotensin II levels, and cardiac hypertrophy in a Cyp1a1-Ren-2 transgenic rat model of malignant hypertension at 10 mg/kg per day.分子式C24H39NO6 • 2Na分子量483.5OCCCC/C=C\CCCCCCC/C=C\CCCCC(NC(C([O-])=O)CC([O-])=O)=O.[Na+].[Na+]