STING Agonist 1a

Agonist-Induced High-Affinity GTP Hydrolysis as an Index of Receptor-Mediated G Protein Activation in Mammalian Brain Membranes

-mediated signal transduction have not yet been fully elucidated, the following scheme is generally accepted (Fig. 1 ). In an inactive state, G protein exists as an associated form of GDP-bound a-subunit and fiy-subunits (Fig. 1A ). When an agonist is bound

三句话读懂一篇 CNS：线粒体突变降低癌症死亡风险 57% 以上​；解密大猩猩捶胸口之谜...

. Wiley 研究组在 Cell Metabolism 杂志上发表论文 Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis，研究发现衰老细胞能够合成并积累细胞内前列腺素 1a, 1b - 二同型 - 15 - 脱氧 -δ-12,14 - 前列腺素 J2（Dihomo-15d-PGJ2），释放的 15 - 脱氧 -δ-12,14 - 前列腺素 J2 是体内和体外衰老的生物标志物。衰老

Visualizing G Protein-Coupled Receptor Signalsomes Using Confocal Immunofluorescence Microscopy

The heptahelical G protein-coupled receptors (GPCRs) receive and transmit a wide range of extracellular stimuli and induce a wide array of cellular responses by activating signaling kinases. It has become increasingly evident that the agonist