Erianin

一种具有多种生物活性的苯甲酰化合物；以钙/钙调蛋白依赖性方式抑制H460和H1299肺癌细胞的生长；在100mg/kg剂量下减少H460小鼠异种移植模型中的肿瘤体积；在DSS诱发的溃疡性结肠炎小鼠模型中增加结肠长度和体重，并减少结肠炎症和结肠溃疡数量；在10mg/kg剂量下减少视网膜小胶质细胞积聚、NF-kB信号传导和TNF-α mRNA表达，并减弱STZ诱发的糖尿病视网膜病变小鼠模型中的血脑屏障破坏。A benzoyl compound with diverse biological activities; inhibits the growth of H460 and H1299 lung cancer cells in a calcium/calmodulin-dependent manner; reduces tumor volume in an H460 mouse xenograft model at 100 mg/kg; increases colon length and body weight, as well as decreases colonic inflammation and the number of colonic ulcers in a mouse model of DSS-induced ulcerative colitis; decreases retinal microglia accumulation, NF-kB signaling, and TNF-α mRNA expression, as well as attenuates blood-brain barrier breakdown in a mouse model of STZ-induced diabetic retinopathy at 10 mg/kg.分子式C18H22O5分子量318.4OC1=CC(CCC2=CC(OC)=C(C(OC)=C2)OC)=CC=C1OC