Ganglioside GT1b (bovine) (amm

具有可变脂肪酰基链长度的牛神经节苷脂GT1b混合物；其特征在于具有与内部半乳糖单元连接的两个唾液酸残基；与神经毒素BTxA、BTxA重链和破伤风毒素结合（IC50s分别为11、0.74和7.2μM）；含有神经节苷脂GT1b的脂质体可以与MCPyV的主要外壳蛋白VP1（一种假定的MCPyV受体）结合；在10μM时分别使人类PBMC中IL-6、IL-10、IgG、IgM和IgA的自发产生减少31.4%、30.5%、60%、59.5%和58%。A mixture of bovine ganglioside GT1b with variable fatty acyl chain lengths; characterized by having two sialic residues linked to the inner galactose unit; binds to the neurotoxins BTxA, BTxA heavy chain, and tetanus toxin (IC50s = 11, 0.74, and 7.2 μM, respectively); ganglioside GT1b-containing liposomes can bind to the major coat protein VP1 from MCPyV, a putative MCPyV receptor; decreases spontaneous production of IL-6, IL-10, IgG, IgM, and IgA in human PBMCs by 31.4, 30.5, 60, 59.5, and 58%, respectively, at 10 μM.分子式C95H162N5O47 • 3NH4 (for stearoyl)分子量2180.5OC[C@H]([C@H]([C@]1([C@H](NC(C)=O)[C@@H](O)C[C@@](C([O-])=O)(O[C@@H]2[C@@H](O)[C@H](O[C@H]3[C@@H]([C@H]([C@@H](O[C@@H]3CO)OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC([R])=O)O)O)O[C@@H]([C@@H]2O[C@@H]4O[C@@H]([C@@H]([C@@H]([C@H]4NC(C)=O)O[C@@H]5O[C@@H]([C@@H]([C@@H]([C@H]5O)O[C@]6(C([O-])=O)C[C@@H]([C@H]([C@]([C@@H]([C@@H](CO)O)O)(O6)[H])NC(C)=O)O)O)CO)O)CO)CO)O1)[H])O)O[C@]7(C([O-])=O)C[C@H](O)[C@@H](NC(C)=O)[C@@]([C@H](O)[C@H](O)CO)([H])O7.[NH4+].[NH4+].[NH4+]