Cetilistat

胰腺脂肪酶抑制剂（对人和大鼠酶的IC50分别为5.95和54.8nM）；在3-100mg/kg的剂量范围内降低大鼠口服脂肪耐受试验中血浆甘油三酯水平的升高；在不影响食物摄入量的情况下减少体重增长，并在高脂饮食引起的肥胖大鼠模型中将血浆甘油三酯和瘦素水平的升高从每天4.9-50.7mg/kg降低；降低感染SARS-CoV-2的Vero E6细胞培养上清液中的病毒载量（EC90=2.9µM），并在斑块减少试验中抑制SARS-CoV-2复制（EC50=1.13µM）。A pancreatic lipase inhibitor (IC50s = 5.95 and 54.8 nM for the human and rat enzymes, respectively); reduces increases in plasma triglyceride levels in an oral fat tolerance test in rats from 3-100 mg/kg; decreases body weight gain without affecting food intake, as well as reduces increases in plasma triglyceride and leptin levels in a rat model of high-fat diet-induced obesity from 4.9-50.7 mg/kg per day; reduces viral load in the culture supernatant of Vero E6 cells infected with SARS-CoV-2 (EC90 = 2.9 µM) and inhibits SARS-CoV-2 replication in a plaque reduction assay (EC50 = 1.13 µM).分子式C25H39NO3分子量401.6O=C1OC(OCCCCCCCCCCCCCCCC)=NC2=C1C=C(C)C=C2