Ganglioside GQ1b (porcine) (am

从猪脑中分离的一种鞘脂分子，主要具有C18:0脂肪酰基链长；在5nM浓度下刺激GOTO人神经母细胞瘤细胞表面几种外型蛋白激酶底物的磷酸化；通过激活ERK1/2通路促进mESC向神经元前体细胞和神经胶质细胞分化；通过磷酸肌醇周转诱导小鼠角质形成细胞分化。A sphingolipid molecular species isolated from porcine brain with primarily C18:0 fatty acyl chain lengths; stimulates phosphorylation of several ecto-type protein kinase substrates on the surface of GOTO human neuroblastoma cells at 5 nM; promotes differentiation of mESCs to neuronal precursor and glial cells via activation of the ERK1/2 pathway; induces differentiation of murine keratinocytes through phosphoinositide turnover.分子式C106H178N6O55 • 4NH4 (for stearoyl)分子量2416.6O=C([O-])[C@]1(C[C@@H]([C@H]([C@@]([H])(O1)[C@H](O)[C@@H](CO)O[C@@]2(C[C@@H]([C@H]([C@@]([H])(O2)[C@H](O)[C@H](O)CO)NC(C)=O)O)C([O-])=O)NC(C)=O)O)O[C@H]3[C@H]([C@H](O[C@H]([C@@H]3O)O[C@@H]4[C@H](O[C@H]([C@@H]([C@H]4O)O)OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC([R])=O)CO)CO)O[C@H]5[C@@H]([C@H]([C@H]([C@H](O5)CO)O)O[C@H]6[C@@H]([C@H]([C@H]([C@H](O6)CO)O)O[C@@]7(C[C@@H]([C@H]([C@@]([H])(O7)[C@H](O)[C@@H](CO)O[C@@]8(C[C@@H]([C@H]([C@@]([H])(O8)[C@H](O)[C@H](O)CO)NC(C)=O)O)C([O-])=O)NC(C)=O)O)C([O-])=O)O)NC(C)=O.[NH4+].[NH4+].[NH4+].[NH4+]