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色氨酸的活性代谢物；在50mM时降低RAW 264.7巨噬细胞中LPS诱导的COX-2、TNF-α、IL-1β和IL-6的表达；在23.4mg/kg时增加LPS诱导的内毒血症小鼠模型和脓毒症小鼠模型的存活率；在100mg/kg时减少A549小鼠异种移植模型中的肿瘤生长和转移数量。An active metabolite of tryptophan; reduces LPS-induced expression of COX-2, TNF-α, IL-1β, and IL-6 in RAW 264.7 macrophages at 50 mM; increases survival in a mouse model of LPS-induced endotoxemia and a mouse model of sepsis at 23.4 mg/kg; reduces tumor growth and the number of metastases in an A549 mouse xenograft model at 100 mg/kg.分子式C12H14N2O3分子量234.3NC(C(O)=O)CC1=CNC2=CC=C(OC)C=C21
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文献和实验相关实验
Synthesis of Oligodeoxynucleotides with 5′‐Caps Binding RNA Targets
‐fluorenylmethylcarboxyl)‐(S )‐pyrrolidin‐3‐methoxy]‐(diisopropylamino)phosphoramidite ( S.8 ; for synthesis, see protocol 4 ) Argon (Ar)
precursors into the bloodstream or from impairment of its hepatic uptake, metabolism, or excretion. (See Jaundice: Impaired bilirubin metabolism .) Jaundice occurs when bilirubin levels exceed 34 to 43 mmol/L (2.0 to 2.5 mg/dl), which is about twice
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5-methoxy-DL-Tryptophan
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