scyllo-Inositol

一种肌醇的立体异构体；在0.1-2µg/µl浓度下减少Aβ40和Aβ42诱导的PC12细胞存活率下降；在阿尔茨海默病的TgCRND8模型中，预防性给药可减少4个月和6个月大小鼠可溶性和不可溶性脑Aβ40和Aβ42水平的增加；从5个月大开始给药，可减少6个月大小鼠不可溶性脑Aβ40和Aβ42水平的增加；与TgCRND8对照小鼠和非转基因同窝对照小鼠相比，可改善Morris水迷宫中已建立的空间学习和记忆缺陷；提高TgCRND8小鼠的存活率。A stereoisomer of inositol; reduces Aβ40- and Aβ42-induced decreases in the survival of PC12 cells at 0.1-2 µg/µl; reduces increases in soluble and insoluble brain Aβ40 and Aβ42 levels in four- and six-month-old mice in the TgCRND8 model of Alzheimer's disease when administered prophylactically; reduces increases in insoluble brain Aβ40 and Aβ42 levels in six-month-old mice when administered starting at five months of age; improves established spatial learning and memory deficits in the Morris water maze when compared with TgCRND8 control and non-transgenic littermate control mice; improves survival of TgCRND8 mice.分子式C6H12O6分子量180.2O[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O