Ectoine

具有光保护和抗炎活性的微生物代谢物；在1mM浓度下可降低分离的人类角质形成细胞中UVA诱导的AP-2活化、ICAM1表达和第二信使释放；在100mg/kg浓度下可减少DSS诱发的结肠炎小鼠模型中的肠隐窝损伤、水肿和白细胞浸润。A microbial metabolite with photoprotectant and anti-inflammatory activities; reduces UVA-induced AP-2 activation, ICAM1 expression, and second messenger release in isolated human keratinocytes at 1 mM; reduces intestinal crypt damage, edema, and leukocyte infiltration in a mouse model of DSS-induced colitis at 100 mg/kg.分子式C6H10N2O2分子量142.2CC1=NCC[C@@H](C(O)=O)N1