(Des-Arg9)-Bradykinin

缓激肽的活性代谢物和缓激肽B1受体的肽激动剂；与缓激肽B1和B2受体结合（在表达人类受体的CHO细胞中IC50=8.1µM）；诱导预收缩的去内皮狗肾动脉条带松弛（pD2=8.6）；以剂量依赖性方式降低接受LPS治疗的兔子的血压。An active metabolite of bradykinin and a peptide agonist of the bradykinin B1 receptor; binds to bradykinin B1 and B2 receptors (IC50 = 8.1 µM in CHO cells expressing the human receptor); induces relaxation of precontracted isolated endothelium-denuded dog renal artery strips (pD2 = 8.6); decreases blood pressure in LPS-treated rabbits in a dose-dependent manner.分子式C44H61N11O10分子量904O=C(N1CCC[C@H]1C(N2CCC[C@H]2C(NCC(N[C@H](C(N[C@@H](CO)C(N3CCC[C@H]3C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)[C@H](CCCNC(N)=N)N[H]