BIMU 8

5-HT4受体激动剂(Ki=69nM)；还可结合5-HT3受体(Ki=0.36nM)；刺激小鼠胚胎丘神经元中cAMP的形成(EC50=72nM)；在30、40和60nmol/只动物的剂量下诱导大鼠额叶皮质释放乙酰胆碱；在0.1、0.3和1mg/kg的剂量下增加清醒狗的餐后胃窦和结肠运动；在20mg/kg的剂量下增加大鼠爪压测试中的缩回潜伏期。A 5-HT4 receptor agonist (Ki = 69 nM); also binds 5-HT3 receptors (Ki = 0.36 nM); stimulates cAMP formation in primary mouse embryonic colliculi neurons (EC50 = 72 nM); induces acetylcholine release in the rat frontal cortex at 30, 40, and 60 nmol/animal; increases postprandial antral and colonic motility in conscious dogs at 0.1, 0.3, and 1 mg/kg; increases the latency to withdraw in the paw pressure test in rats at 20 mg/kg.分子式C19H26N4O2 • HCl分子量378.9O=C(N1C(N(C(C)C)C2=C1C=CC=C2)=O)N[C@@H]3C[C@@H]4CC[C@@H](N4C)C3.Cl