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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
2-8℃
- 保质期:
见包装
- 英文名:
Tetrandrine
- 库存:
大量现货
- 供应商:
上海研谨生物
- CAS号:
518-34-3
- 规格:
20mg
粉防己碱
分析标准品,HPLC≥98%
Tetrandrine
CAS号:518-34-3
分子式:C38H42N2O6
分子量:622.75
MDL:MFCD08689909
别名:汉防己碱;汉防己甲素
|
货号 |
规格/参数/品牌 |
价格 |
货期 |
|
YJ-B20392-20mg |
分析标准品,HPLC≥98% |
¥270.00 |
现货 |
|
YJ-B20392-1g |
分析标准品,HPLC≥98% |
¥1980.00 |
现货 |
|
JS31752-1g |
≥97% |
¥1100.00 |
现货 |
|
JS31752-5g |
≥97% |
¥3030.00 |
现货 |
|
A10217-20mg |
分析标准品,含量99.8%,可溯源 |
¥600.00 |
现货 |
|
JT94066-1ml买5赠1 |
10mM in DMSO |
¥325.00 |
现货 |
产品介绍
Tetrandrine (NSC-77037; d-Tetrandrine) 是一种双苯基异喹*啉生物碱,抑制电压门控钙离子通道 (ICa) 和 Ca2+ 激活的钾离子通道。
熔点:219-222℃
沸点:710.5℃ at 760 mmHg
比旋光度:285 º (c=1, CHCl3)
外观:无色针状结晶(乙mi)
溶解性:DMSO : 5 mg/mL (8.03 mM; Need ultrasonic and warming)
储存条件:2-8℃
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文献和实验参考文献(21篇)
21. [IF=4] Tan Lihua et al."In-vitro Evaluation of p-Sulfonatocalix[n] arenes (SCnA) as Novel Excipients Using a Vectorized BCS Approach."AAPS PHARMSCITECH.2025 Oct;26(7):1-17
20. [IF=1.3] Yu Wang et al."Tetrandrine Improves Ventricular Remodeling and Inflammation via Inhibition of the MAPK/NF-κB Pathway."International Heart Journal.
19. [IF=2.5] Li Chen et al."Optimization of Extraction Process of Total Alkaloids from Thalictrum delavayi Franch. and Their Therapeutic Potential on Pulmonary Infection Caused by Klebsiella pneumoniae and Escherichia coli."Separations.2024 Jul;11(7):210
18. [IF=4.7] Xu Zhang et al."Rhein: A potent immunomodulator empowering largemouth bass against MSRV infection."FISH & SHELLFISH IMMUNOLOGY.2024 Jan;144:109284
17. [IF=3.3] Zhang Xueyan et al."A (Traditional Chinese Medicine) TCM-Inspired Doxorubicin Resistance Reversing Strategy: Preparation, Characterization, and Application of a Co-loaded pH-Sensitive Liposome."AAPS PHARMSCITECH.10.1208/s12249-023-02630-8
16. [IF=7.419] Bichen Li et al."Total alkaloids in Stephania tetrandra induce apoptosis by regulating BBC3 in human non–small cell lung cancer cells."BIOMEDICINE & PHARMACOTHERAPY.2023 Jun;162:114635
15. [IF=5.988] Jun Li et al."Screening of anti-heart failure active compounds from fangjihuangqi decoction in verapamil-induced zebrafish model by anti-heart failure index approach.."Frontiers in Pharmacology.2022 Oct;13:999950-999950
14. [IF=3.024] Xuan Yu et al."An innovative extraction strategy for herbal medicine by adopting p-sulphonatocalix[6]/[8]arenes."PHYTOCHEMICAL ANALYSIS
13. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950
12. [IF=4.411] Dan Liao et al."Tetrandrine Interaction with ABCB1 Reverses Multidrug Resistance in Cancer Cells Through Competition with Anti-Cancer Drugs Followed by Downregulation of ABCB1 Expression."Molecules. 2019 Jan;24(23):4383
11. [IF=4.769] Zhenzhong Yang et al."Deciphering bioactive compounds of complex natural products by tandem mass spectral molecular networking combined with an aggregation-induced emission based probe."J Pharm Anal. 2020 Nov;:
10. [IF=4.939] Mengjuan Jiang et al."Reduction-sensitive Paclitaxel Prodrug Self-assembled Nanoparticles with Tetrandrine Effectively Promote Synergistic Therapy Against Drug-sensitive and Multidrug-resistant Breast Cancer."Mol Pharmaceut. 2017;14(11):3628–3635
9. [IF=5.64] Wu Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466
8. Yang, Zhenzhong, et al. "Deciphering bioactive compounds of complex natural products by tandem mass spectral molecular networking combined with an aggregation-induced emission based probe." Journal of Pharmaceutical Analysis (2020).https:##doi.org/10.1016/
7. Mengjuan Jiang, Ruoshi Zhang, Yingli Wang, Wenna Jing, Ying Liu, Yan Ma, Bingjun Sun, Menglin Wang, Peizhuo Chen, Hongzhuo Liu, and Zhonggui He,Reduction-sensitive Paclitaxel Prodrug Self-assembled Nanoparticles with Tetrandrine Effectively Promote Synergi
6. 何婉婉 张建逵 李云静 康廷国.北豆根药材粉末色泽与有效成分的相关性[J].中国实验方剂学杂志 2017 23(05):57-62.
5. 何婉婉 张建逵 李云静 康廷国.北豆根显微特征指数与化学成分相关性[J].中国实验方剂学杂志 2017 23(01):42-46.
4. 胡筱希 朱荣 唐新 等. 响应曲面法优化防己中汉防己甲素及汉防己乙素的提取工艺[J]. 中国民族民间医药 2020 v.29;No.366(01):29-34.
3. 张克清, 戴珍, 李彦萍. 粉防己碱激活Akt/GSK-3b信号通路保护心肌I/R大鼠研究[J]. 新中医, 2018, 050(009):12-17.
2. 郭孝玉, 张潇月, 李奇勇,等. 粉防己碱对铜绿微囊藻的化感作用[J]. 三明学院学报, 2017, 034(006):57-61.
1. 杨敬宁, 张燕, 王敏,等. 粉防己碱对胡蜂毒素致多器官功能障碍综合征大鼠的保护作用[J]. 中国工业医学杂志, 2018, 31(05):12-13+83.
、疟原虫的耐药性 当前防治疟疾所遇到的最大困难是恶性疟原虫对抗疟药,特别是对氯喹,其次是对奎宁、乙胺嘧啶等产生耐药性。而且耐氯喹的虫株常对乙胺嘧啶和周效磺胺等有交叉耐药性。恶性疟是流行最广、对人类危害性最大的一种疾病。因此亟需寻找新型抗疟药。近国外报道钙拮抗药(包括粉防己碱)与氯喹合用,能部分恢复疟原虫对氯喹的敏感性。
疟原虫对抗疟药,特别是对氯喹,其次是对奎宁、乙胺嘧啶等产生耐药性。而且耐氯喹的虫株常对乙胺嘧啶和周效磺胺等有交叉耐药性。恶性疟是流行最广、对人类危害性最大的一种疾病。因此亟需寻找新型抗疟药。近国外报道钙拮抗药(包括粉防己碱)与氯喹合用,能部分恢复疟原虫对氯喹的敏感性。
疟原虫对抗疟药,特别是对氯喹,其次是对奎宁、乙胺嘧啶等产生耐药性。而且耐氯喹的虫株常对乙胺嘧啶和周效磺胺等有交叉耐药性。恶性疟是流行最广、对人类危害性最大的一种疾病。因此亟需寻找新型抗疟药。近国外报道钙拮抗药(包括粉防己碱)与氯喹合用,能部分恢复疟原虫对氯喹的敏感性。
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