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- Sigma-Aldrich
- 进口
- H8000-5G
- 2025年07月19日
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- 技术资料
- 保存条件：
常温
- 保质期：
根据瓶身LOT号查询
- 英文名：
L-Histidine
- 库存：
有现货
- 供应商：
浙江羽翔生物科技有限公司
- CAS号：
71-00-1
- 规格：
5G
属性
Product Name
L-组氨酸, ReagentPlus®, ≥99% (TLC)
质量水平
200
产品线
ReagentPlus®
方案
≥99% (TLC)
表单
powder
颜色
white to off-white
mp
282 °C (dec.) (lit.)
溶解性
0.5 M HCl: 50 mg/mL
应用
cell analysis
SMILES字符串
N[C@@H](Cc1c[nH]cn1)C(O)=O
InChI
1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
InChI key
HNDVDQJCIGZPNO-YFKPBYRVSA-N
基因信息
human ... CA1(759), CA2(760)
应用
生化/生理作用
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文献和实验Systematic Nanoscale Analysis of Endocytosis Links Efficient Vesicle Formation to Patterned Actin Nucleation.
Clathrin-mediated endocytosis is an essential cellular function in all eukaryotes that is driven by a self-assembled macromolecular machine of over 50 different proteins in tens to hundreds of copies. How these proteins are organized to produce endocytic vesicles with high precision and efficiency is not understood. Here, we developed high-throughput superresolution microscopy to reconstruct the nanoscale structural organization of 23 endocytic proteins from over 100,000 endocytic sites in yeast. We found that proteins assemble by radially ordered recruitment according to function. WASP family proteins form a circular nanoscale template on the membrane to spatially control actin nucleation during vesicle formation. Mathematical modeling of actin polymerization showed that this WASP nano-template optimizes force generation for membrane invagination and substantially increases the efficiency of endocytosis. Such nanoscale pre-patterning of actin nucleation may represent a general design principle for directional force generation in membrane remodeling processes such as during cell migration and division.
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