7-Amino-3,6-dichloro-3-phenyl-

Synthesis of 3-Amino-l-CarboxymethyI-Benzodiazepine (BZA) Peptidomimetics

inhibitors of Ras famesyltransferase (FTase) (6 ,7 ). The central pair of amino acids in the CAAX tetrapeptide was replaced with the nonpeptide scaffold 3-methylamino-1-carboxymethyl-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one, (N -Me)BZA, shown below.

Oligodeoxynucleotide Containing S‐Functionalized 2′‐Deoxy‐6‐Thioguanosine: Facile Tools for Base‐Selective and Site‐Specific Internal Modification of

the selective functionalization of the 4?amino group of the cytosine base at pH 7 or the 2?amino group of the guanine base at pH 9.4 or at pH 7.4 in the presence of NiCl2 . In particular, the functionality?transfer reaction (FTR) under the alkaline conditions

Two‐Step, One‐Pot Synthesis of Inosine, Guanosine, and 2′‐Deoxyguanosine O6‐Ethers via Intermediate O6‐(Benzotriazol‐1‐yl) Derivatives

to 2,6‐dichloro, 2‐amino‐6‐chloro, and derived purine nucleosides. Can. J. Chem. 59:2601‐2607.    Robins, M.J. and Uznański, B. 1981b. Nucleic acid related compounds. 34. Nonaqueous