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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
5-Aminolevulinic Acid Hydrochloride
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
5451-09-2
- 规格：
100mg/50mg/20mg
| 规格： | 100mg | 产品价格： | ￥540.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥420.0 |
| 规格： | 20mg | 产品价格： | ￥220.0 |
是一种化合物，具有生物或化学活性。
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Engineering a probiotic strain of Escherichia coli to induce the regression of colorectal cancer through production of 5-aminolevulinic acid
成员:Junhao Chen, Xiaohong Li, Yumei Liu, Tianyuan Su, Changsen Lin, Lijun Shao, Lanhua Li, Wanwei Li, Guoyu Niu, Jing Yu, Ling Liu, Miaomiao Li, Xiaoli Yu, Qian Wang
论文因子:5.813 发表期刊:Microbial Biotechnology pmid:34272828
| 基本信息 | |
| CAS | No.5451-09-2 |
| 中文名称 | 5-氨基乙酰PPA盐酸盐 |
| 英文名称 | 5-Aminolevulinic Acid Hydrochloride |
| 别名 | 氨基酮戊酸;5-ALA;Hydrangin;ALA hydrochloride;δ-Aminolevulinic acid hydrochloride;5-Amino-4-oxopentanoic acid hydrochloride |
| 分子式 | C5H9NO3·HCl |
| 分子量 | 167.59 |
| 溶解性 | Soluble in Water ≥25mg/mL |
| 纯度 | ≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 226-679-5 |
| MDL | MFCD00012869 |
| SMILES | O=C(O)CCC(CN)=O.[H]Cl |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | 5-Aminolevulinic Acid Hydrochloride是一种化合物,具有生物或化学活性。 |
| 生物活性 | 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles. 5-Aminolevulinic acid hydrochloride (ALA) is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumours. [1-2] |
| In Vitro | Median follow-up was 35.4 months(95% CI 1.0-56.7). Contrast-enhancing tumour was resected completely in 90(65%)of 139 patients assigned 5-aminolevulinic acid compared with 47(36%)of 131 assigned white light(difference between groups 29% [95% CI 17-40]，p<0.0001). Patients allocated 5-aminolevulinic acid had higher 6-month progression free survival than did those allocated white light(41.0% [32.8-49.2] vs 21.1% [14.0-28.2]; difference between groups 19.9% [9.1-30.7]，p=0.0003，Z test)[1]. 5-ALA alone proved to be insufficient in attaining gross total resection without the danger of incurring postoperative neurological deterioration. Furthermore，in the case of functional grade III gliomas，iMRI in combination with functional neuronavigation was significantly superior to the 5-ALA resection technique[2] . |
| 数据来源文献 | [1]. Stummer， W.， et al.， Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol， 2006. 7(5): p. 392-401. [2]. Eyupoglu， I.Y.， et al.， Improving the extent of malignant glioma resection by dual intraoperative visualization approach. PLoS One， 2012. 7(9): p. e44885. |
| 单位 | 瓶 |
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文献和实验【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Engineering a probiotic strain of Escherichia coli to induce the regression of colorectal cancer through production of 5-aminolevulinic acid
成员:Junhao Chen, Xiaohong Li, Yumei Liu, Tianyuan Su, Changsen Lin, Lijun Shao, Lanhua Li, Wanwei Li, Guoyu Niu, Jing Yu, Ling Liu, Miaomiao Li, Xiaoli Yu, Qian Wang
论文因子:5.813 发表期刊:Microbial Biotechnology pmid:34272828
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