IS2410 抗坏血酸钠 维生素及其衍生物 索莱宝

In Vitro

synthesized proteins （5mM sodium ascorbate for 2 h）

Experimental procedures for AHA labeling of synthesized proteins were adapted from a published protocol. The sample was incubated at 95 °C for 10 min. Click reaction was then performed after the samples were cooled to 37 °C in a reaction system containing 50 μMAcety-lene-PEG4-Biotin, 0.1 mM GuSO4,0.5 mM THPTA , and

5mM sodium ascorbate (Solarbio) for 2 h. The reaction was terminated with 1 mM EDTA. The labeled proteins were resolved by SDS–PAGE and detected with Biotin detection reagents.

来源文献：Wang P, Zhang L, Chen S, Li R, Liu P, Li X, Luo H, Huo Y, Zhang Z, Cai Y, Liu X, Huang J, Zhou G, Sun Z, Ding S, Shi J, Zhou Z, Yuan R, Liu L, Wu S, Wang G. ANT2 functions as a translocon for mitochondrial cross-membrane translocation of RNAs. Cell Res. 2024 Jul;34(7):504-521. doi: 10.1038/s41422-024-00978-5. Epub 2024 May 29. PMID: 38811766; PMCID: PMC11217343.

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标题:ANT2 functions as a translocon for mitochondrial cross-membrane translocation of RNAs

成员:Wang Pengcheng, Zhang Lixiao, Chen Siyi, Li Renjian, Liu Peipei, Li Xiang, Luo Hongdi, Huo Yujia, Zhang Zhirong, Cai Yiqi, Liu Xu, Huang Jinliang, Zhou Guangkeng, Sun Zhe, Ding Shanwei, Shi Jiahao, Zhou Zizhuo, Yuan Ruoxi, Liu Liang, Wu Sipeng, Wang Geng

论文因子:28.1 发表期刊:CELL RESEARCH pmid:38811766

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标题:Comparison of Composition, Free-Radical-Scavenging Capacity, and Antibiosis of Fresh and Dry Leave Aqueous Extract from Michelia shiluensis

成员:Wentao Wu, Gaoyu Li, Weijuan Zhou, Enbo Wang, Xia Zhao, Xiqiang Song, Ying Zhao

论文因子:4.6 发表期刊:MOLECULES pmid:37630187

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标题:Integrated multifunctional nanoplatform for fluorescence detection and inactivation of Staphylococcus aureus

成员:Jing-bo Jiao, Qing Kang, Jiang-li Cao, Shuai-qi Zhang, Chen-jing Ma, Tong Lin, Ze-hui Xiao, Chu-min Zhao, Ting Du, Xin-jun Du, Shuo Wang

论文因子:8.8 发表期刊:FOOD CHEMISTRY pmid:37413833

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标题:Fracture strength and bonding interface morphology of CAD/CAM-fabricated ceramic laminate veneers on bleached enamel treated with two different antioxidants

成员:Hong ZHANG, Jiawen CHEN, Ying WANG, Yiyan YU, Yuanhang ZHAO, Jiazhuo SONG, Zhimin ZHANG

论文因子:2.5 发表期刊:DENTAL MATERIALS JOURNAL pmid:37302824

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标题:Fracture strength and bonding interface morphology of CAD/CAM-fabricated ceramic laminate veneers on bleached enamel treated with two different antioxidants

成员:Zhang H; Chen J; Wang Y; Yu Y; Zhao Y; Song J; Zha

论文因子:2.5 发表期刊:Dent Mater J pmid:37302824

基本信息
CAS	No.134-03-2
中文名称	抗坏血酸钠
英文名称	Sodium Ascorbate
别名	(+)-Sodium L-ascorbate;Sodium L-ascorbate;L-Ascorbic acid sodium;Vitamin C sodium salt;维生素C钠;L-Ascorbic acid sodium salt
分子式	C6H7NaO6
分子量	198.11
溶解性	Soluble in Water ≥10mg/mL
纯度	≥98%
外观(性状)	Off-white to light yellow Solid
储存条件	Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
EC	EINECS 205-126-1
MDL	MFCD00082340
SMILES	C(C(C1C(=C(C(=O)O1)O)[O-])O)O.[Na+]
靶点	Cav3.2 channels
通路	Membrane Transporter&Ion Channel;Neuronal Signaling
背景说明	Sodium Ascorbate是一种电子供体和内源性抗氧化剂，还是一种胶原沉积促进剂和弹性生成抑制剂。Sodium Ascorbate可以选择性抑制 Cav3.2 通道(Cav3.2 channels)。
生物活性	L-Ascorbic acid sodium salt (Sodium L-ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor[1-3].
In Vitro	The conditioned medium for B16F10 cells significantly inhibits cell apoptosis induced by L-Ascorbic acid sodium salt(Sodium L-ascorbate)(10 mM)，and the effective ingredients in the medium show a relative molecular mass below 5，000[4].
细胞实验	Tg rats treated with L-Ascorbic acid sodium salt(Sodium L-ascorbate)show a higher incidence of carcinoma(29.6%)，compared to those without L-Ascorbic acid sodium salt(15.4%). Independent of the L-Ascorbic acid sodium salt treatment，transgenic rats exhibit various kinds of malignant tumors in various organs[5].
动物实验	A total of 40 7-week-old male Tg rats are divided into 2 groups. Twenty-seven(group 1)and 13(group 2)rats are given a powdered MF diet with or without 5% sodium L-ascorbate，respectively. Similarly，a total of 42 7-week-old male Non-tg rats are divided into 2 groups，and 30(group 3)and 12(group 4)animals are given a diet with or without 5% sodium L-ascorbate，respectively.[3]
数据来源文献	[1]. Hinek A， et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82. [2]. Aleksander Hinek， et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82. [3]. Michael T Nelson， et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83. [4]. Yang X， et al. Mouse melanoma cell line B16F10-derived conditioned medium inhibits sodium L-ascorbate-induced B16F10 cell apoptosis. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Feb;32(2):146-50. [5]. Morimura K， et al. Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol. 2005;33(7):764-7. [6]. Takagi H， et al. Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model. Cancer Lett. 2005 Mar 10;219(2):147-53.
单位	瓶