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- 详细信息
- 技术资料
- 保存条件：
Store at 2-8℃，2 years
- 保质期：
Store at 2-8℃，2 years
- 英文名：
4-Fomepizole
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
7554-65-6
- 规格：
1g/500mg
| 规格： | 1g | 产品价格： | ￥590.0 |
|---|---|---|---|
| 规格： | 500mg | 产品价格： | ￥410.0 |
| 基本信息 | |
| CAS | No.7554-65-6 |
| 中文名称 | 4-甲基吡唑 |
| 英文名称 | 4-Fomepizole |
| 别名 | Antizol-Vet;4-Methylpyrazole;Antizol;甲吡唑;Fomepizole |
| 分子式 | C4H6N2 |
| 分子量 | 82.1 |
| 溶解性 | Soluble in Water/DMSO |
| 纯度 | ≥98% |
| 外观(性状) | Light yellow Liquid |
| 储存条件 | Store at 2-8℃，2 years |
| 密度 | 0.993g/mL |
| 熔点 | 13℃ |
| EC | EINECS 231-445-0 |
| MDL | MFCD00005245 |
| SMILES | CC1=CNN=C1 |
| InChIKey | RIKMMFOAQPJVMX-UHFFFAOYSA-N |
| InChI | InChI=1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6) |
| PubChem CID | 3406 |
| 靶点 | Alcohol dehydrogenase，CYP2E1 |
| 通路 | Metabolic Enzyme&Protease |
| 背景说明 | 4-Fomepizole是一种有效的细胞色素 P450 (CYP2E1) 抑制剂。4-Fomepizole是竞争性的乙醇脱氢酶 (alcohol dehydrogenase) 抑制剂。 |
| 生物活性 | 4-Methylpyrazole， an alcohol dehydrogenase inhibitor， exacerbates alcohol-induced microencephaly during the brain growth spurt[1] |
| 细胞实验 | 4-MP is an effective nontoxic ADH inhibitor and that microencephaly is associated with BAC levels.[1] |
| 动物实验 | Four groups of artificially reared Sprague-Dawley rat pups were treated with alcohol treatment(3.3 g/kg EtOH or isocalorically matched control formula from postnatal days 4 through 9)and 4-MP administration(IP，50 mg/kg or saline). A suckle control group was introduced to control the effects of the artificial rearing procedure. On postnatal day 10，all pups were perfused. Alcohol in combination with 4-MP treatment produced a marked microencephaly，as assessed by brain weights or brain to body weight ratios，compared with other artificially reared groups.[1] |
| 数据来源文献 | [1]. Chen WJ， McAlhany RE Jr， West JR. 4-Methylpyrazole， an alcohol dehydrogenase inhibitor， exacerbates alcohol-induced microencephaly during the brain growth spurt. Alcohol. 1995 Jul-Aug;12(4):351-5. |
| 单位 | 瓶 |
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IF1190 4-甲基吡唑 代谢酶/蛋白酶 索莱宝
￥410 - 590
