IP9010 泊洛沙姆407 助溶剂/增溶剂 索莱宝

是非离子型表面活性剂，有特殊的反向热胶凝作用，刺激性小，生物相容性好，是一个理想的药物控释材料

使用本产品的案例（仅供参考）

In Vivo

Rabbit ( mature female New Zealand white rabbits (weight 2.5 ±0.5 kg);  injected into rabbits with 10 Fr catheter continuously for five days）

The mature female New Zealand white rabbits (weight 2.5 ±0.5 kg) were maintained under standardized laboratory (temperature 20 ± 2℃, relative humidity 45 ± 10%).    Forage and water were qualified.Normal saline, P407 gel, LDH-P407 gel and nonoxinol gel were injected into rabbits with 10 Fr catheter continuously for five days. The rabbits were sacrificed on the sixth day and the vaginal tissues were dissected.

来源文献：Tian W, Han S, Huang X, Han M, Cao J, Liang Y, Sun Y. LDH hybrid thermosensitive hydrogel for intravaginal delivery of anti-HIV drugs. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1234-1240. doi: 10.1080/21691401.2019.1596935. Retraction in: Artif Cells Nanomed Biotechnol. 2021 Dec;49(1):555. PMID: 30966834.    

Mice（SPF-grade male SD rats, aged 6–8 weeks and weighing 160-180 g intraperitoneally injected,10% Poloxam 407 ,at a dose of 0.25 g/kg at an interval of 48 h until Day 14.）

In the C group, 10% Poloxam 407 (P-407) (Solarbio, Beijing, China) was intraperitoneally injected at a dose of 0.25 g/kg at an interval of 48 h until Day 14.

来源文献：Wang L, Ren Y, Xu T, Geng J, Yang N, Wang R. Triglycerides: A Sensitizer but Not a Trigger for Hypertriglyceridemic Acute Pancreatitis. Dig Dis Sci. 2024 Jun;69(6):2123-2131. doi: 10.1007/s10620-024-08412-x. Epub 2024 Apr 12. PMID: 38609542.

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标题:AGR2-induced cholesterol synthesis drives lovastatin resistance that is overcome by combination therapy with allicin

成员:Sheng Nan, Wang Yun-qiu, Wang Cun-fu, Jia Meng-qi, Niu Huan-min, Lu Qi-qi, Wang Ya-nan, Feng Dan, Zheng Xiao-xue, Yuan Hui-qing

论文因子:7.169 发表期刊:ACTA PHARMACOLOGICA SINICA pmid:35459869

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标题:Injectable thermo-responsive Poloxamer hydrogel/methacrylate gelatin microgels stimulates bone regeneration through biomimetic programmed release of SDF-1a and IGF-1

成员:Qiang Zhong, Ding Wang, Huaming Mai, Rong Chen, Yixin Xu, Mingyuan Lei, Jiajun Xie, Zinan Tang, Jinlang Fu, Yuhang Chen, Jian Wang, Zhanjun Shi, Hao Cheng

论文因子:8.2 发表期刊:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES pmid:38821297

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标题:Bioinspired engineering ADSC nanovesicles thermosensitive hydrogel enhance autophagy of dermal papilla cells for androgenetic alopecia treatment

成员:Jiachao Xiong, Zhixiao Liu, Lingling Jia, Yulin Sun, Rong Guo, Tingting Xi, Zihan Li, Minjuan Wu, Hua Jiang, Yufei Li

论文因子:18.9 发表期刊:Bioactive Materials pmid:38440324

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标题:A magnetic multi-layer soft robot for on-demand targeted adhesion

成员:Chen Ziheng, Wang Yibin, Chen Hui, Law Junhui, Pu Huayan, Xie Shaorong, Duan Feng, Sun Yu, Liu Na, Yu Jiangfan

论文因子:16.6 发表期刊:Nature Communications pmid:38245517

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标题:MicroRNA-92a -mediated endothelial to mesenchymal transition controls vein graft neointimal lesion formation

成员:Zhong CM;Li S;Wang XW;Chen D;Jiang ZL;Zhang C;He XJ;Huang C;Jiang YJ;Wu QC.

论文因子:3.7 发表期刊:Exp Cell Res pmid:33253710

基本信息
CAS	No.9003-11-6
中文名称	泊洛沙姆407
英文名称	Poloxamer 407
别名	Poloxamer-407
分子式	No data available
溶解性	Soluble in Water ≥100mg/mL
外观(性状)	White to off-white Solid
储存条件	Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
EC	EINECS 618-355-0
MDL	MFCD00082049
背景说明	是非离子型表面活性剂,有特殊的反向热胶凝作用,刺激性小,生物相容性好,是一个理想的药物控释材料。
细胞实验	In order to efficiently transfer the Adeno-associated virus(AAV)into the vein graft walls and avoid any potential systemic side effects，we used a local delivery method by using poloxamer-407(Solarbio，Beijing China)with trypsin as our previously described [14，15，17]. Briefly，after end to end anastomosis of the vein segment to common carotid artery，30ul AAV6-anti-miR-92a or AAV6-control(Shanghai GeneChem，Co.，Ltd. Shanghai，China)fluid was preloaded into 120 μl 25% poloxamer-407 pluronic gel containing 0.25% trypsin at 4 C，and was gently painted around the grafted vein segments.[1]
数据来源文献	[1]. Zhong CM， Li S， Wang XW， Chen D， Jiang ZL， Zhang C， He XJ， Huang C， Jiang YJ， Wu QC. MicroRNA-92a -mediated endothelial to mesenchymal transition controls vein graft neointimal lesion formation. Exp Cell Res. 2021 Jan 1;398(1):112402
单位	瓶