- ￥240 - 780
- Solarbio
- 北京
- IR1050
- 2025年07月23日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: 2-8℃，2 years
- 保质期：
Powder: 2-8℃，2 years
- 英文名：
Rotundine
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
10097-84-4
- 规格：
100mg/50mg/20mg
| 规格： | 100mg | 产品价格： | ￥780.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥500.0 |
| 规格： | 20mg | 产品价格： | ￥240.0 |
| 基本信息 | |
| CAS | No.10097-84-4 |
| 中文名称 | 罗通定 |
| 英文名称 | Rotundine |
| 别名 | 延胡索乙素 |
| 分子式 | C21H25NO4 |
| 分子量 | 355.43 |
| 溶解性 | Soluble in DMSO ≥0.1mg/mL(Need ultrasonic) |
| 纯度 | HPLC≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder: 2-8℃，2 years |
| EC | EINECS 1592732-453-0 |
| MDL | MFCD00214191 |
| SMILES | COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC |
| InChIKey | AEQDJSLRWYMAQI-UHFFFAOYSA-N |
| InChI | InChI=1S/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3 |
| PubChem CID | 5417 |
| 靶点 | 5-HT1A，dopamine D1、D2 |
| 通路 | Neuronal Signaling;GPCR & G Protein |
| 背景说明 | 是一种多巴胺受体拮抗剂，也能有效抑制5-HT1A。 |
| 生物活性 | Tetrahydropalmatine possesses analgesic effects. Tetrahydropalmatine acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats[1]. |
| 细胞实验 | Tetrahydropalmatine(THP)，an active component isolated from corydalis(a Chinese herbal medicine)，possesses analgesic effects. Picrotoxin treatment alone has a significant effect on the following activity measure: there is an increase in horizontal motion time(HMT)，vertical motion time(VMT)，clockwise turnings(CT)，anticlockwise turning(ACT)and a decrease in freezing time(FT). Tetrahydropalmatine treatment alone causes a decrease in HMT，VMT and total distance traveled(TDT)，but an increase in FT. Pretreatment of rats with an i.p. dose of 10 mg/kg or 15 mg/kg of Tetrahydropalmatine significantly attenuates the Picrotoxin-induced enhancement in HMT，VMT，CT，ACT and TDT，as well as reduction in FT. Another 48 rats under urethane anesthesia are randomly divided into six groups，each of eight rats. The s.c. injection of Picrotoxin causes an increase in amygdaloid release of dopamine(DA)，while i.p. injection of Tetrahydropalmatine at 10 mg/kg has an insignificant effect on amygdaloid release of DA. Again，the Picrotoxin-induced increase in amygdaloid release of DA is significantly attenuated by pretreatment with Tetrahydropalmatine. The Picrotoxin-induced augmented amygdaloid release of DA is almost completely abolished by pretreatment with Tetrahydropalmatine 30 min before s.c. injection of Picrotoxin[1]. |
| 动物实验 | Male Sprague-Dawley rats，weighing 250-320 g，are used in the present study. The animals are housed in a temperature-regulated(22±1°C)room on 12:12 h light/dark cycles with food and water available ad libitum. The light is turned on at 06:00 h and turned off at 18:00 h. At least two major groups of animals are studied.(1)Vehicle-treated rats: received an i.p. injection of 0.9% saline plus Picrotoxin(3-4 mg/kg，s.c.).(2)Tetrahydropalmatine-treated rats: receive an injection of Tetrahydropalmatine(10 mg/kg，i.p.)plus Picrotoxin(3-4 mg/kg，s.c.). The effects of s.c. administration of Picrotoxin or Tetrahydropalmatine on locomotor activity are assessed in unanesthetized rats. On the other hand，the effects of Picrotoxin or Tetrahydropalmatine on amygdaloid DA release are assessed in rats under urethane(1.4 g/kg，i.p.)anesthesia.Seventy-two unanesthetized rats are randomly divided into nine groups，each of eight rats. The animals are adapted to the behavior apparatus for 30 min before an injection of Picrotoxin(3 or 4 mg/kg，s.c.)，Tetrahydropalmatine(10 or 15 mg/kg，i.p.)or saline. Then，the locomotor activities of these rats are recorded during the 30-min period following the injections[1]. |
| 数据来源文献 | [1]. Chang CK， et al. DL-Tetrahydropalmatine may act through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats. Neurosci Lett. 2001 Jul 20;307(3):163-6. |
| 单位 | 瓶 |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验相关专题 胰岛素受体信号通路 ： The appropriate signaling through the insulin pathway is critical for the regulation of glucose levels and the avoidance of diabetes. Insulin forms a complex with the Insulin Receptor (IR
578475733 因最近要做蛋白激酶C在糖尿病方面的实验，求助各位高手有没有蛋白激酶C信号通路的图片，最好带注解，十分感谢。 石依信念 我也想要～～～～ 黑胡桃 [img]data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAskAAAGdCAYAAADgwu6RAAAgAElEQVR4Aey9B7xdxZXmu04
分类，经过GO注释后发现，PCOS-NIR与PCOS-IR病人在免疫应答反应中的甲基化基因有显著的差异，此外，癌症信号通路上的基因在两组中均有显著的甲基化差异。这篇研究有助于更好的阐明PCOS发生的分子机制。 本文是由上海仁济医院的狄文教授与苏州大学神经科学研究所的曹聪教授共同合作完成的，其团队主要采用MeDIP技术完成了对PCOS疾病的分子机制的研究，该服务由上海生物芯片有限公司/生物芯片上海国家工程研究中心提供。 该研究设立了三个组，分别是：PCOS-NIR病人
技术资料暂无技术资料 索取技术资料
