7-Bromo-2-tert-butyl-imidazo[1

Release of DNA Oligonucleotides and Their Conjugates from Controlled‐Pore Glass Under Thermolytic Conditions

. Tetrahedron Lett. 42:5635‐5639.    Wilk, A., Chmielewski, M.K., Grajkowski, A., Phillips, L.R., and Beaucage, S.L. 2002. The 3‐[(N‐tert‐butyl)carboxamido]‐1‐propyl group

Synthesis of Peptide‐Oligonucleotide Conjugates by Diels‐Alder Cycloaddition in Water

) N α ‐(9‐Fluorenylmethoxycarbonyl)‐protected amino acids (Fmoc‐aa‐OH; Novabiochem, Bachem): e.g., for sequences illustrated here, Arg(Pbf), Gly, Leu, Phe, Ser(t Bu), and Tyr(t Bu) (t Bu: tert ‐butyl; Pbf

Biotinylation of a Propargylated Cyclic (3′‐5′) Diguanylic Acid and of Its Mono‐6‐Thioated Analog Under “Click” Conditions

) N 2 ‐Isobutyryl‐5′‐O ‐(4,4′‐dimethoxytrityl)‐2′‐O ‐propargyl‐3′‐O ‐[(N,N ‐diisopropylamino) 2‐cyanoethyloxyphosphinyl]guanosine ( 3 , ChemGenes) 5.5 M tert ‐butyl