4-Chloro-N-(2-chloro-2-cyano-e

Determination of Sulfur Amino Acids, Glutathione, and Related Aminothiols in Biological Samples by Gas Chromatography with Flame Photometric Detection

. Although GC method based on the preparation of N-heptafluorobutyryl isobutyl or ethyl esters (8 ) is selective and sensitive by flame photometric detection (FPD), this method is not applied to the analysis of biological samples. As the HPLC methods

Synthesis and Properties of 7‐Substituted 7‐Deazapurine (Pyrrolo[2,3‐d]pyrimidine) 2′‐Deoxyribonucleosides

of 7‐bromo‐7‐deaza‐2′‐deoxyisoguanosine (S.4c ) is carried out by glycosylation of a brominated nucleobase followed by amination at C4 and selective deamination at C2′. NBS, N ‐bromosuccinimide; Piv, pivaloyl; TDA‐1, tris[2‐(2‐methoxyethoxy)ethyl]amine

Conjugation of 5′‐Functionalized Oligodeoxyribonucleotides with Properly Functionalized Ligands

Dichloromethane or ethyl acetate (for very lipophilic ligands) 4% (w/v) LiClO 4 in distilled acetone, or n ‐butanol (for ligands of medium lipophilicity