Oleamide

油酸酰胺和CB1受体激动剂(Ki=8.13µM)；对CB1受体的选择性优于CB2受体，在100µM浓度下，在表达人类CB2受体的HEK-293T细胞中，它仅抑制42.5%的CB受体完全激动剂CP55,940的结合；抑制福斯高林诱导的N1E115小鼠神经母细胞瘤细胞中的cAMP积累；在5-50mg剂量下诱导大鼠生理性睡眠；增加大鼠的食物摄入量，并对群居和社会隔离小鼠产生抗焦虑样作用；诱导PPARα、PPARβ和PPARγ的转录激活；抑制SERCA。An amide of oleic acid and agonist of CB1 receptors (Ki = 8.13 µM); selective for CB1 over CB2 receptors, where it inhibits binding of the CB receptor full agonist CP55,940 by only 42.5% in HEK-293T cells expressing human CB2 receptors at 100 µM; inhibits forskolin-induced cAMP accumulation in N1E 115 mouse neuroblastoma cells; induces physiological sleep in rats at 5-50 mg; increases food intake in rats and anxiolytic-like effects in group-housed and socially isolated mice; induces transactivation of PPARα, PPARβ, and PPARγ; inhibits SERCA.分子式C18H35NO分子量281.5CCCCCCCC/C=C\CCCCCCCC(N)=O