(S)-Acenocoumarol

短效口服抗凝剂醋硝香豆素的对映体，与(R)-对映体(6.6小时，1.9升/小时)相比，其血浆消除半衰期更短(1.8小时)，血浆清除率更快(28.5升/小时)；在从胃肠道吸收过程中会经历广泛的首过代谢；体内效力低于(R)-对映体。An enantiomer of the short-lived oral anti-coagulant acenocoumarol with a shorter plasma elimination half-life (1.8 hours) and faster plasma clearance (28.5 L/hour), compared to the (R)-enantiomer (6.6 hours, 1.9 L/hour); undergoes extensive first-pass metabolism during absorption from the gastrointestinal tract; less potent in vivo than the (R)-enantiomer.分子式C19H15NO6分子量353.3O=C1C([C@](CC(C)=O)([H])C2=CC=C([N+]([O-])=O)C=C2)=C(O)C3=CC=CC=C3O1