PPOH

通过所谓的环氧化酶途径，微粒体CYP450酶将花生四烯酸转化为多种环氧化物、ω-1和ω-羟基化化合物。PPOH是特定CYP450同工酶催化的环氧化反应的选择性抑制剂。PPOH抑制CYP4A2和CYP4A3酶形成花生四烯酸11,12环氧化物，IC50值为9µM，但对CYP4A1的ω-羟基化产物20-HETE的形成有影响。Arachidonic acid is converted by microsomal CYP450 enzymes to a variety of epoxides, ω-1 and ω-hydroxylated compounds via what is known as the epoxidase pathway. PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes. PPOH inhibits the formation of arachidonate 11,12 epoxides by CYP4A2 and CYP4A3 enzymes with an IC50 value of 9 µM, but has effect on the formation of 20-HETE, the ω-hydroxylation product of CYP4A1.分子式C15H18O3分子量246.3C#CCOC1=CC=CC=C1CCCCCC(O)=O