PAD2 Inhibitor Screening Assay

PAD2是一种胍基修饰酶，以钙依赖的方式催化特定精氨酸残基转化为瓜氨酸。这种酶与多种疾病有关，包括类风湿性关节炎(RA)、视网膜变性和某些癌症。PAD2已被证明可以修饰波形蛋白、纤维蛋白原和β/γ-肌动蛋白。吸烟者肺部的PAD2细胞外水平升高，这表明吸烟是RA的风险因素，与RA患者中的抗瓜氨酸化蛋白抗体之间存在联系。Cayman的PAD2抑制剂筛选检测试剂盒(AMC)提供了一种筛选人类PAD2抑制剂的便捷方法。PAD2 is a guanidino-modifying enzyme that catalyzes the conversion of specific arginine residues to citrulline in a calcium-dependent manner. This enzyme has been implicated in several diseases, including rheumatoid arthritis (RA), retinal degeneration, and certain cancers. PAD2 has been shown to modify vimentin, fibrinogen, and β/γ-actin. Extracellular levels of PAD2 are increased in the lungs of smokers, providing a link between smoking as a risk factor for RA and anti-citrullinated protein antibodies among RA patients. Cayman's PAD2 Inhibitor Screening Assay Kit (AMC) provides a convenient method for screening human PAD2 inhibitors.分子式分子量