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文献和实验1B1 are each active in the oxidation of theophylline (11 ), caffeine (11 , 12 ), estradiol (13 , 14 ), benzo[a]pyrene (11 ) and 7-ethoxyresorufin (11 ). With 7-ethoxyresorufin as substrate, the rank order of specific activity (pmol/min/nmol P450) is CYP1A1
253322.1|AF253322 Homo sapiens cytochrome P450 (CYP1A1) and cytochrome P450 (CYP1A2) genes, complete cds Length = 43064 Score = 44.1 bits (22), Expect = 0.013 Identities = 22/22 (100%) Strand = Plus / Plus Query: 21 ttaggagtcttgtctcatgcct 42
Experimental Approaches for the Study of Cytochrome P450 Gene Regulation
This chapter uses cytochrome P450 1A1 (CYP1A1) as a model “xenobiotic inducible” gene and the aryl hydrocarbon receptor (AHR) as a regulator of this gene product to illustrate how studies may be performed to understand the relationships
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