- ￥2860
- LSM Bio
- 进口
- PAab09609
- 2025年07月16日
- ELISA,WB,IF,IP
- E. coli - derived recombinant protein
- Human, Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
zinc finger, CCHC domain containing 11
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
O95498
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IF,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
zinc finger, CCHC domain containing 11
- 抗体英文名：
anti-ZCCHC11 antibody,ZCCHC11 antibody
- 抗体名：
anti-ZCCHC11 抗体,ZCCHC11 抗体
- 规格：
100μl
ZCCHC11抗体| ZCCHC11 antibody
货号 PAab09609
蛋白别名 KIAA0191 antibody, PAPD3 antibody, Terminal uridylyltransferase 4 antibody, TUT4 antibody, TUTase 4 antibody, ZCCHC11
蛋白介绍
Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Does not bind RNA directly, but recruited to RNA targets by RNA-binding protein LIN28A. Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (By similarity). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation. Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.
产品描述
anti-ZCCHC11 antibody is a Rabbit Polyclonal antibody againstZCCHC11..
建议稀释比例
WB : 1:200-1:2000;IP:1:500-1:5000;IF:1:20-1:200
IHC
Western blot
MCF7 cells were subjected to SDS PAGE followed by western blot with PAab09609(ZCCHC11 antibody) at dilution of 1:500(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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