- ￥2860
- LSM Bio
- 进口
- PAab09555
- 2025年07月16日
- ELISA,WB,IHC,IF,IP
- E. coli - derived recombinant protein
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
O95498
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,IF,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
- 抗体英文名：
anti-XRCC5/Ku80 antibody,XRCC5/Ku80 antibody
- 抗体名：
anti-XRCC5/Ku80 抗体,XRCC5/Ku80 抗体
- 规格：
100μl
XRCC5/Ku80抗体| XRCC5/Ku80 antibody
货号 PAab09555
蛋白别名 86 kDa subunit of Ku antigen antibody, CTC85 antibody, CTCBF antibody, DNA repair protein XRCC5 antibody, FLJ39089 antibody, G22P2 antibody, KARP 1 antibody, KARP1 antibody, Ku80 antibody, Ku86 antibody, KUB2 antibody, NFIV antibody, Nuclear factor IV antibody, Thyroid lupus autoantigen antibody, TLAA antibody, XRCC5
蛋白介绍
There are at least two pathways for eukaryotes to repair DNA double-strand breaks: homologous recombination and nonhomologous end joining(NHEJ). The core NHEJ machinery includes XRCC4, DNA ligase IV and the DNA-dependent protein kinase complex, which consists of the DNA end-binding XRCC5/XRCC6 heterodimer and the catalytic subunit PRKDC. The heterdimer of XRCC5/XRCC6 enhanced teh affinity of the catalytic subunit PRKDC to DNA by 100-fold. Once the XRCC5/6 dimer association with NAA15, it can bind to the osteocalcin promoter and activate osteocalcin expression. The XRCC5/6 dimer acts as a negative regulator of transcription when together with APEX1. Some publised papers indicated that the MW of XRCC5 is 86kDa, while more papers suggested that XRCC5 is a 80kDa protein, as it was firstly introducted in publication. Thus, Ku80 and Ku86 are the same protein.
产品描述
anti-XRCC5/Ku80 antibody is a Rabbit Polyclonal antibody againstXRCC5/Ku80..
建议稀释比例
WB:1:500-1:5000;IHC:1:20-1:200;IF:1:20-1:200;IP:1:500-1:5000
IHC
Immunohistochemistry of paraffin-embedded human colon cancer using PAab09555(XRCC5 antibody) at dilution of 1:100
Western blot
HepG2 cells were subjected to SDS PAGE followed by western blot with PAab09555(XRCC5 antibody) at dilution of 1:1000(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验a look from the following website just by clicking "Tyrosine Phosphorylation and Dimerization" http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSN-43F85YV-2&_user=1111158&_coverDate=06%2F29%2F2001&_rdoc=1&_fmt=full&_orig=search
扫描仪中，都采用机械式的二维X，Y线性扫描技术实现，即X，Y方向都采用直线驱动器和直线导轨实现往复运动。此类装置，由于驱动系统的频率限制，驱动器的扫描惯性大，使得扫描效率低，分析时间相当长；并且往复行程长，对直线导轨的精度要求相当高。二、光机结合的二维扫描系统为同样实现生物芯片的二维扫描，我们的实验装置设计如图2，采用了振镜和大数值孔径的远心f-è物镜相结合实现X方向扫描，Y方向的运动仍采用直线驱动器和直线导轨实现。 系统中，对于f-è物镜，满足x＝2fè（è为振镜的摆动角度，f为物镜焦距）的线性
Analysis of RB Action in DNA Damage Checkpoint Response
checkpoint response: (1) transcriptional repression of E2F-regulated genes (cyclin A reporter assay); (2) induction of cell cycle arrest (Brd-U incorporation assay); and (3) inhibition of DNA double-strand break accumulation (phosphorylated-histone H2A.X
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