- ￥2860
- LSM Bio
- 进口
- PAab09555
- 2025年07月16日
- ELISA,WB,IHC,IF,IP
- E. coli - derived recombinant protein
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
O95498
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,IF,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
- 抗体英文名：
anti-XRCC5/Ku80 antibody,XRCC5/Ku80 antibody
- 抗体名：
anti-XRCC5/Ku80 抗体,XRCC5/Ku80 抗体
- 规格：
100μl
XRCC5/Ku80抗体| XRCC5/Ku80 antibody
货号 PAab09555
蛋白别名 86 kDa subunit of Ku antigen antibody, CTC85 antibody, CTCBF antibody, DNA repair protein XRCC5 antibody, FLJ39089 antibody, G22P2 antibody, KARP 1 antibody, KARP1 antibody, Ku80 antibody, Ku86 antibody, KUB2 antibody, NFIV antibody, Nuclear factor IV antibody, Thyroid lupus autoantigen antibody, TLAA antibody, XRCC5
蛋白介绍
There are at least two pathways for eukaryotes to repair DNA double-strand breaks: homologous recombination and nonhomologous end joining(NHEJ). The core NHEJ machinery includes XRCC4, DNA ligase IV and the DNA-dependent protein kinase complex, which consists of the DNA end-binding XRCC5/XRCC6 heterodimer and the catalytic subunit PRKDC. The heterdimer of XRCC5/XRCC6 enhanced teh affinity of the catalytic subunit PRKDC to DNA by 100-fold. Once the XRCC5/6 dimer association with NAA15, it can bind to the osteocalcin promoter and activate osteocalcin expression. The XRCC5/6 dimer acts as a negative regulator of transcription when together with APEX1. Some publised papers indicated that the MW of XRCC5 is 86kDa, while more papers suggested that XRCC5 is a 80kDa protein, as it was firstly introducted in publication. Thus, Ku80 and Ku86 are the same protein.
产品描述
anti-XRCC5/Ku80 antibody is a Rabbit Polyclonal antibody againstXRCC5/Ku80..
建议稀释比例
WB:1:500-1:5000;IHC:1:20-1:200;IF:1:20-1:200;IP:1:500-1:5000
IHC
Immunohistochemistry of paraffin-embedded human colon cancer using PAab09555(XRCC5 antibody) at dilution of 1:100
Western blot
HepG2 cells were subjected to SDS PAGE followed by western blot with PAab09555(XRCC5 antibody) at dilution of 1:1000(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验
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