- ￥2260
- LSM Bio
- 进口
- PAab09432
- 2025年07月15日
- ELISA,WB,IHC,IF
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
vacuolar protein sorting 26 homolog A (S. pombe)
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
O95498
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,IF
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
vacuolar protein sorting 26 homolog A (S. pombe)
- 抗体英文名：
anti-VPS26A antibody,VPS26A antibody
- 抗体名：
anti-VPS26A 抗体,VPS26A 抗体
- 规格：
100μl
VPS26A抗体| VPS26A antibody
货号 PAab09432
蛋白别名 FLJ12930 antibody, HB58 antibody, Hbeta58 antibody, hVPS26 antibody, PEP8A antibody, Vesicle protein sorting 26A antibody, VPS26 antibody, VPS26A
蛋白介绍
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of FAM21A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo reognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer- independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity).
产品描述
anti-VPS26A antibody is a Rabbit Polyclonal antibody againstVPS26A..
建议稀释比例
IHC:1:20-1:200;IF:1:20-1:200
IHC
Immunohistochemistry of paraffin-embedded human kidney tissue slide using PAab09432( VPS26A Antibody) at dilution of 1:200
Western blot
HEK-293 cells were subjected to SDS PAGE followed by western blot with PAab09432( VPS26A Antibody) at dilution of 1:300(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验
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