- ￥2260
- LSM Bio
- 进口
- PAab09352
- 2025年07月16日
- ELISA,WB,IF
- E. coli - derived recombinant protein
- Human, Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
UV radiation resistance associated gene
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IF
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
UV radiation resistance associated gene
- 抗体英文名：
anti-UVRAG antibody,UVRAG antibody
- 抗体名：
anti-UVRAG 抗体,UVRAG 抗体
- 规格：
100μl
UVRAG抗体| UVRAG antibody
货号 PAab09352
蛋白别名 DHTX antibody, p63 antibody, UVRAG
蛋白介绍
Versatile protein that is involved in regulation of differenent cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:24056303). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3. Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA- dependent protein kinase complex DNA-PK and activating it in non- homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840).
产品描述
anti-UVRAG antibody is a Rabbit Polyclonal antibody againstUVRAG..
建议稀释比例
WB :1:500-1:5000;IP:1:200-1:2000；IF:1:10-1:100
IHC
Western blot
HepG2 cells were subjected to SDS PAGE followed by western blot with PAab09352(UVRAG antibody) at dilution of 1:500(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验
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