- ￥2262
- LSM Bio
- 进口
- PAab08865
- 2025年07月15日
- ELISA,WB,IHC,IP
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
topoisomerase (DNA) I
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
topoisomerase (DNA) I
- 抗体英文名：
anti-TOP1 antibody,TOP1 antibody
- 抗体名：
anti-TOP1 抗体,TOP1 抗体
- 规格：
100μg
TOP1抗体| TOP1 antibody
货号 PAab08865
蛋白别名
蛋白介绍
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the ARNTL/BMAL1 promoter.
产品描述
anti-TOP1 antibody is a Rabbit Polyclonal antibody againstTOP1..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human cervical cancer using PAab08865(TOP1 antibody) at dilution of 1:50
Western blot
L02 cells were subjected to SDS PAGE followed by western blot with PAab08865(TOP1 antibody) at dilution of 1:300(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验
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