- ￥2262
- LSM Bio
- 进口
- PAab08729
- 2025年07月15日
- ELISA,WB
- E. coli - derived recombinant protein
- Human, Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
toll-like receptor 6
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
toll-like receptor 6
- 抗体英文名：
anti-TLR6 antibody,TLR6 antibody
- 抗体名：
anti-TLR6 抗体,TLR6 抗体
- 规格：
100μg
TLR6抗体| TLR6 antibody
货号 PAab08729
蛋白别名
蛋白介绍
Participates in the innate immune response to Gram- positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides (PubMed:20037584). In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (PubMed:11441107). In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid- beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B- dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion (PubMed:11441107, PubMed:20037584).
产品描述
anti-TLR6 antibody is a Rabbit Polyclonal antibody againstTLR6..
建议稀释比例
IHC
Western blot
(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验人 Toll 样受体 6(TLR6) 酶联免疫分析 试剂盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定人血清，细胞上清及相关液体样本中 Toll 样受体6(TLR6) 的含量。 实验原理： 本试剂盒应用双抗体夹心法测定标本中 人 Toll 样受体6(TLR6) 水平。用纯化的人 Toll 样受体6(TLR6) 抗体包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入 Toll 样受体6(TLR6
of TLR2 can form functional pairs with TLR6 and TLR1, leading to signal transduction and cytokine gene expression. All TLRs activate signalling pathways that are similar to those activated by IL-1, because they share a Toll/IL-1R homology domain
章)。后者又称为内吞型PRR，有甘露糖受体、清道夫受体(SR)、N-甲酰甲硫氨酰受体、Toll样受体(TLR)、NLR受体等。甘露糖受体可特异性识别并结合微生物细胞壁糖蛋白和糖脂组分中的末端甘露糖和岩藻糖残基，从而介导Mφ的吞噬作用；SR可与细菌细胞壁的某些组分结合，有效地清除血循环中的细菌；TLR是一类跨膜受体，通过识别并结合相应PAMP，可启动激活信号转导途径，并诱导某些免疫分子(包括炎性细胞因子)表达。 已发现TLR有11种，TLRl、TLR2、TLR4、TLR5、TLR6
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