- ￥2262
- LSM Bio
- 进口
- PAab08395
- 2025年07月15日
- ELISA,WB,IP
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
suppressor of Ty 6 homolog (S. cerevisiae)
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
suppressor of Ty 6 homolog (S. cerevisiae)
- 抗体英文名：
anti-SUPT6H antibody,SUPT6H antibody
- 抗体名：
anti-SUPT6H 抗体,SUPT6H 抗体
- 规格：
100μg
SUPT6H抗体| SUPT6H antibody
货号 PAab08395
蛋白别名 KIAA0162 antibody, SPT6H
蛋白介绍
Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.
产品描述
anti-SUPT6H antibody is a Rabbit Polyclonal antibody againstSUPT6H..
建议稀释比例
IHC
Western blot
(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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