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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
squalene epoxidase
- 亚型:
IgG
- 形态:
liquid
- 保存条件:
负20摄氏度
- 克隆性:
Polyclonal antibody
- 标记物:
Non-conjugated
- 适应物种:
Human,Mouse ,Rat
- 保质期:
6个月
- 抗原来源:
Rabbit
- 目录编号:
P67936
- 级别:
纯化级别
- 库存:
50
- 供应商:
LSM bio
- 宿主:
E. coli - derived recombinant protein
- 应用范围:
ELISA,WB,IHC,IP,IF
- 浓度:
≥95% as determined by SDS-PAGE
- 靶点:
squalene epoxidase
- 抗体英文名:
anti-SQLE antibody,SQLE antibody
- 抗体名:
anti-SQLE 抗体,SQLE 抗体
- 规格:
100μg
SQLE抗体| SQLE antibody
货号 PAab08209
蛋白别名 ERG1 antibody, FLJ30795 antibody, SE antibody, SM antibody, SQLE antibody, squalene epoxidase antibody, Squalene monooxygenase
蛋白介绍
SQLE, also named as ERG1, SE and SM, belongs to the squalene monooxygenase family. It catalyzes the first oxygenation step in cholesterol synthesis, acting on squalene before cyclization into the basic steroid structure. SQLE may serve as a flux-controlling enzyme beyond 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR, considered as rate limiting). It is also posttranslationally regulated by cholesterol-dependent proteasomal degradation.(PMID:21356516) The MW of SQLE is about 64kd.
产品描述
anti-SQLE antibody is a Rabbit Polyclonal antibody againstSQLE..
建议稀释比例
WB : 1:200-1:2000 IP : 1:200-1:1000 IHC : 1:20-1:200 IF : 1:20-1:200
IHC
Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using PAab08209( SQLE Antibody) at dilution of 1:50
Western blot
A549 cells were subjected to SDS PAGE followed by western blot with PAab08209(SQLE antibody) at dilution of 1:300(本抗体仅供体外科研用途,不可用于临床诊断!) "">
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文献和实验Mol Cell:秦骏等发现结直肠癌患者分型标志物,他汀类药物或可治疗这类癌症
途径基因座上的 ZMYND8 和 SREBP2 峰的分析表明,SREBP2 优先在启动子区域招募,而 ZMYND8 占据了 H3K4me1 和 H3K27ac 修饰标记的增强子和启动子区域。接下来研究团队选择 HMGCR、SQLE 和 FDFT1 作为模型基因,并进行染色体构象捕获(3C)分析以检测增强子和启动子是否在物理上接近。研究团队观察到 HMGCR、SQLE 和 FDFT1 基因的明显增强子 - 启动子相互作用,而 SREBP2 或 ZMYND8 KO 消除了接触。一系列分析
的 Egr-1 直接抑制 patatin 样磷脂酶结构域 2(ATGL)转录的并抑制脂肪细胞的脂肪分解。Egr-1 还影响关键胆固醇合成基因 Hmgcr,Cyp51,Me1 和 Sqle 的转录,并促进胆固醇合成代谢。 此外,之前的工作已经证明,Egr-1 在年轻小鼠的肝脏中有节律地表达,并且是肝脏中几个核心时钟基因的昼夜节律表达模式所必需的;它特别调节生物节律基因 Per1 的转录活性。另一方面,Egr-1 的节律也受 BMAL1/CLOCK 异二聚体表达的调节。因此,研究者推测 Egr-1 可能
Evaluation of Rett Syndrome Symptom Improvement by Metabolic Modulators in Mecp2‐Mutant Mice
itself is part of a negative feedback mechanism that adjusts levels of the rate‐limiting enzymes HMGCR and SQLE. Lipid synthesis is regulated in part by the accumulation of lipids in adipocytes, which produce adipokines, such as leptin and adiponectin. In turn
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