- ￥2262
- LSM Bio
- 进口
- PAab07331
- 2025年07月14日
- ELISA,WB,IF,IHC
- E. coli - derived recombinant protein
- Human,Rat, Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Rat, Mouse
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IF,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
- 抗体英文名：
anti-RNASEL antibody,RNASEL antibody
- 抗体名：
anti-RNASEL 抗体,RNASEL 抗体
- 规格：
100μg
RNASEL抗体| RNASEL antibody
货号 PAab07331
蛋白别名 RNS4
蛋白介绍
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress- response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979). Might play a central role in the regulation of mRNA turnover (PubMed:11585831).
产品描述
anti-RNASEL antibody is a Rabbit Polyclonal antibody againstRNASEL..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human spleen tissue slide using PAab07331( RNASEL Antibody) at dilution of 1:50
Western blot
RAW 264.7 cells were subjected to SDS PAGE followed by western blot with PAab07331( RNASEL Antibody) at dilution of 1:600(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验
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