- ￥2262
- LSM Bio
- 进口
- PAab02901
- 2025年07月16日
- ELISA,WB,IHC,IF
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
exosome component 2
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9WVH4
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,IF
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
EXOSC2
- 抗体英文名：
anti-EXOSC2 antibody,EXOSC2 antibody
- 抗体名：
anti-EXOSC2 抗体,EXOSC2 抗体
- 规格：
100μl
EXOSC2抗体| EXOSC2 antibody
货号 PAab02901
蛋白别名 RRP4
蛋白介绍
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.
产品描述
anti-EXOSC2 antibody is a Rabbit Polyclonal antibody againstEXOSC2..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human skin cancer using PAab02901(EXOSC2 antibody) at dilution of 1:100
Western blot
HeLa cells were subjected to SDS PAGE followed by western blot with PAab02901(EXOSC2 antibody) at dilution of 1:500(本抗体仅供体外科研用途，不可用于临床诊断!)
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文献和实验
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