- ￥2062
- LSM Bio
- 进口
- PAab00461
- 2025年07月14日
- ELISA,WB,IHC
- E. coli - derived recombinant protein
- Human, Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
adaptor-related protein complex 2, alpha 2 subunit
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9GZT9
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
AP2A2
- 抗体英文名：
anti-AP2A2 antibody,AP2A2 antibody
- 抗体名：
anti-AP2A2 抗体,AP2A2 抗体
- 规格：
100μg
AP2A2抗体| AP2A2 antibody
货号 PAab00461
蛋白别名 ADTAB antibody, CLAPA2 antibody, HIP9 antibody, HYPJ antibody, KIAA0899
蛋白介绍
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C- terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity).
产品描述
anti-AP2A2 antibody is a Rabbit Polyclonal antibody againstAP2A2..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human testis tissue slide using PAab00461( AP2A2 Antibody) at dilution of 1:50
Western blot
mouse brain tissue were subjected to SDS PAGE followed by western blot with PAab00461( AP2A2 Antibody) at dilution of 1:300(本抗体仅供体外科研用途，不可用于临床诊断!)
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