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文献和实验N-Linked Protein Glycosylation in a Bacterial System
N -Linked protein glycosylation is conserved throughout the three domains of life and influences protein function, stability, and protein complex formation. N -Linked glycosylation is an essential process in Eukaryotes; however, although N
, the serogroup B meningococcal polysaccharide when conjugated to a protein carrier still failed to give a significant immune response ( 2 , 3 ). This phenomenon is probably attributed to the molecular mimicry between the polysaccharide and human
Isolation of Low-n Amyloid -Protein Oligomers from Cultured Cells, CSF, and Brain
Recent data suggest that soluble, non-fibrillar assemblies of the amyloid β-protein (Aβ) may mediate the synaptic deficits that characterize the early stages of Alzheimer’s disease. Consequently, much effort has been expended in isolating
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