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文献和实验Interaction of the Presenilins with the Amyloid Precursor Protein (APP)
the deposition of amyloid Aβ peptide. The latter is released from its cognate amyloid precursor protein (APP) by a two-step proteolytic conversion: first, proteolysis of APP by β-secretase, which releases the N-terminus of Aβ, and second, conversion
α-Synuclein/Amyloid Interactions
of the 39-42 amino acid residue peptide Aβ arranged in β-pleated sheets. Aβ is generated by hydrolysis from the transmembrane amyloid precursor protein APP. The mechanism by which the intracellular presynaptic α-synuclein or its NAC fragment
[3]Zhang YW，Thompson R，Zhang H，et al．APP processing in Alzheimer's disease．Mol Brain，2011，4:3． [4]Sastre M，Steiner H，Fuchs K，et al．Presenilin-dependent gamma-secretes processing of beta-amyloid precursor protein at a site corresponding to the S3
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