Hepatitis B X Protein / HBx ra

gene_symbol：X Protein
predicted_size：null
Uniprot ID
description：Hepatitis B X Protein / HBx rabbit polyclonal antibody, Aff - Purified
clonality：Polyclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：The recombinant Hepatitis B Protein X is 100% homologous with the natural Hepatitis B Protein X. Hepatitis B virus X protein (HBx) is a 17 kD transcriptional coactivator that plays a significant role in the regulation of genes involved in inflammation and cell survival. It regulates many transcription factors including nuclear factor kappa B (NF-kappaB) and plays a key role in hepatocarcinogenesis. HBx facilitates the binding of cAMP response element binding protein (CREB) to its responsive element. HBx stabilizes the cellular coactivator ASC-2 through direct protein-protein interaction, affecting the regulation of genes actively transcribed in liver cancer cells. HBx transactivates both JNK and MAPK signal transduction pathways in association with the mobilization of cytosolic Ca2+. The communication between HBx and general transcription factor TFIIB is also one of the mechanisms which account for its transcriptional transactivation. HBx decreased the expression of PTEN a known tumor suppressor and a negative regulator of phosphatidylinositol 3'-kinase/AKT and HBx decreased the expression of PTEN in HBx-transfected cells. The etiology of hepatocellular carcinoma (HCC) is involved with hepatitis B virus (HBV) infection and HBx in particular plays a role in the development of HBV-related HCC. The persistence of HBx is important to the pathogenesis of early HCC and HBx expression in the liver during chronic HBV infection may be an important prognostic marker for the development of HCC.
immunogen：Recombinant Hepatitis B Protein X from E. coli.
recommended_dilution：ELISA. (Titer is defined by Indirect ELISA, it is > 1/100,000 for antibody concentration 1 mg/ml, 25 ng of antigen are coated per well, and is then defined at a point of maximal decrease of the titration curve). Western blotting. Immunoprecipitaion.
predicted_size：null
buffer：0.05M Phosphate buffer, 0.1M NaCl, pH 7.2 without preservatives; State: Aff - Purified; State: Lyophilized purified IgG fraction
host_species：Rabbit
applications：ELISA, IP, WB
reactivities：Hepatitis B Virus