PAI1 (SERPINE1) mouse monoclon

gene_symbol：SERPINE1
predicted_size：null
Uniprot ID：P5121
description：PAI1 (SERPINE1) mouse monoclonal antibody, clone MA-33H1F7, Purified
clonality：Monoclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：

Plasminogen activator inhibitor type-1 (PAI-1), a member of the serine protease inhibitor (serpin) superfamily, is an important protein in the regulation of fibrinolysis. PAI-1 is unique among the serpins because of its functional and conformational flexibility. PAI-1 is the most important physiological inhibitor of both tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). Increased PAI-1 levels are associated with thrombotic events and is an established risk factor for cardiovascular diseases. The active conformation PAI-1 inhibits its target proteinases by the formation of a stable, inactive complex. Although PAI-1 is synthesized as an active molecule, it converts spontaneously to an inactive, latent form that can be partially reactivated by denaturing agents. In addition, a third conformation reacting as a non-inhibitory substrate towards various target proteinases has been identified.
The epitope of monoclonal antibody MA-33H1F7 is predominantly composed of three residues (Lys154/Glu130/Arg131), positioned virtually linearly in the three-dimensional structure.

immunogen：null
recommended_dilution：Functional assay: Antibody MA-33H1F7 functions as an antagonist. The antibody was  incubated with active PAI-1 and residual activity was measured by a functional assay (Ref.1). Western blot: A non-reduced sample treatment and SDS-Page was used. The band size is 52 kDa (Ref.5). The typical starting working dilution is 1:50. Immunassay.
predicted_size：null
buffer：PBS; State: Purified; State: Liquid 0.2 µm filtered Ig fraction; Stabilizer: 0.1% bovine serum albumin
host_species：Mouse
applications：ELISA, FN, WB
reactivities：Human, Mouse, Rat