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文献和实验zsping7411 有哪位高手知道PI3K细胞信号传导通路与HO-1的关系的,因为我发现在脑、肝、心肌器官的文献说PI3K通路激活,磷酸化PI3K增加,上调HO-1的表达,最后抑制细胞凋亡发挥保护作用,而在中性粒细胞(PMN)方面,PI3K激活促进PMN募集趋化作用,所以在胰腺炎、脓毒症等引起的ALI中应用PI3K抑制剂渥漫青霉素或LY294002则表现为抑制PMN在肺内聚集,所以减轻了ALI,似乎很矛盾,请问有谁能解释一下!非常感谢!可以回复至zsping
Quantitation of Heme Oxygenase (HO-1) Copies in Human Tissues by Competitive RT/PCR
A variety of oxidative stress-inducing agents, such as metals, ultra-violet (UV) light, heme, and hemoglobin have been implicated in the pathogenesis of the inflammatory process. The cellular response to such agents involves the production
As the key enzyme in heme degradation, heme oxygenase activity governs cellular heme concentration. Heme oxygenase catalyzes the conversion of heme to carbon monoxide and bilirubin with the release of iron, which can drive the synthesis
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