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文献和实验中科院高福院士课题组 2020 年发表了哪些重要的研究成果?
抗体的主要靶标。2020 年 3 月 11 日,高福院士联合逯光文在 Cell Host & Microbe 发文:Structural Analysis of Rabies Virus Glycoprotein Reveals pH-Dependent Conformational Changes and Interactions with a Neutralizing Antibody。该研究报告了狂犬病毒 RABV-G 的晶体结构,分别在〜pH-8.0 时以游离形式和在〜pH-6.5 时与中和
A Genetic Model to Dissect the Role of Tsc-mTORC1 in Neuronal Cultures
Tuberous sclerosis complex (TSC) is an autosomal dominant disease caused by mutations in either of two genes, TSC1 or TSC2 , whose protein products form a complex that is essential in the regulation of mammalian target of rapamycin (mTOR
) (1 ) and TSC2 on chromosome 16p13 (MIM * 191092) (2 ). TSC affects up to 1 in 6000 individuals with two-thirds representing sporadic cases, reflecting a high spontaneous mutation rate. Both TSC genes cover about 50 kb and 40 kb of genomic DNA, respectively
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