PHOSPHO-P300 (SER89) ANTIBODY-

Using Phospho‐Motif Antibodies to Determine Kinase Substrates

comprising both the phosphorylated residue and the surrounding residues that determine kinase specificity, with degenerate residues taking up the remaining positions. Currently, several categories of phospho?motif antibody are commercially available

Signaling Events Initiated by Kappa Opioid Receptor Activation: Quantification and Immunocolocalization Using Phospho-Selective KOR, p38 MAPK, and KIR

kinase is KIR 3.1 and have developed a phospho-selective antibody against the Y12 motif of this channel. Much like KOR and p38 MAP kinase, phosphorylation of this potassium channel increases following repeated stress. The following chapter discusses

【求助】P53的翻译后修饰都有哪些？ 怎样验证其修饰后与靶标启动子的结合活性的变化？

酰转移酶p300的结合增强，从而增加了p53的水平和稳定性。Ser15可在IR（电离辐射）或UV（紫外线）作用下发生磷酸化。同时IR 或UV 还可以分别通过活化CHK2（细胞周期关卡激酶2）和CHK1（细胞周期关卡激酶1）引起Ser20的磷酸化。 除常见的72位密码子多态性外，p53肿瘤还可显示一种少见的47位残基上的单核苷酸多态现象，野生型p53在此残基上编码脯氨酸，而在少数人群中编码的则是丝氨酸。此残基临近的Ser46被p38磷酸化后可以显著增强p53诱导凋亡的能力，而Ser-47多态