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文献和实验Tissue-Specific Ablation of Tsc1 in Pancreatic Beta-Cells
Tuberous sclerosis complex 1 (TSC1) is a tumor suppressor that associates with TSC2 to inactivate Rheb, thereby inhibiting signaling by the mammalian target of rapamycin (mTOR) complex 1 (mTORC1). mTORC1 stimulates cell growth by promoting
is associated with some of the most severe clinical problems of TSC, including epilepsy, intellectual disability, and abnormal behavioral phenotypes. Inactivating mutations have been identified in two disease-causing genes, TSC1 on chromosome 9q34 (MIM *191100
趣味研究 | Nature:胸小的原因找到了,原来是.....
夏天到了,太平公主们该发愁了,我是多垫几层海绵呢,还是多吃木瓜呢,如此等等,各种丰胸办法都用上。其实要我来说,真没啥用,别浪费钱了,天生的,基因决定的。不行我们来看看 Nature 上的一篇文章《Tsc1 deficiency impairs mammarydevelopment in mice by suppression of AKT, nuclear ERα》,从标题就可以看出 Tsc1 缺失会影响小鼠发育,到底是怎么影响的呢?Tsc1 缺失下调了 AKT, nuclear ER
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