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文献和实验中科院高福院士课题组 2020 年发表了哪些重要的研究成果?
抗体的主要靶标。2020 年 3 月 11 日,高福院士联合逯光文在 Cell Host & Microbe 发文:Structural Analysis of Rabies Virus Glycoprotein Reveals pH-Dependent Conformational Changes and Interactions with a Neutralizing Antibody。该研究报告了狂犬病毒 RABV-G 的晶体结构,分别在〜pH-8.0 时以游离形式和在〜pH-6.5 时与中和
Functional Analysis of Mutant Mitochondrial DNA Polymerase Proteins Involved in Human Disease
DNA polymerase γ (pol γ) is the only DNA polymerase within the mitochondrion and is thus essential for replication and repair of mtDNA. POLG , the gene encoding the catalytic subunit of pol γ, is a major locus for a wide spectrum
Measurement of Mitochondrial DNA Copy Number
disorders characterized by a significant reduction in mtDNA content. These genes include POLG , DGUOK , TK2 , TYMP , MPV17 , SUCLA2 , SUCLG1 , RRM2B , and C10orf2 , all nine genes have mutations reported to cause various forms of MDDSs. In this chapter
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