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文献和实验such as neuronal differentiation and bone loss. To produce these effects IL-6 signals through a receptor composed of two different subunits, an alpha subunit that produces ligand specificity and gp130, a receptor subunit shared in common with other cytokines
Cytokine Receptors: Qualitative and Quantitative Analysis
(1 ). The relationship between IL-6 and multiple myeloma is probably more complex, involving other cytokines that signal through receptors, which share the gp130 chain with the IL-6 receptor. Another strong association is that of IL-2 with acute T-cell lymphoma/leukemia
The Regenerative Activity of Interleukin-6
, for the regeneration of the liver and for the stimulation of B-cells. IL-6 binds to a transmembrane IL-6 receptor (IL-6R), which is present on hepatocytes and some leukocytes. The complex of IL-6 and IL-6R associates with a second protein, gp130
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