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文献和实验between subtypes of G protein-coupled receptors (GPCRs; endothelin ETA and ETB ), (1 ) in sections of human tissue or whole-body sections of mice, as well as mapping previously designated orphan receptors (oGPCR) recently paired with their cognate ligand
G Protein-Coupled Receptors Disrupted in Human Genetic Disease
occurring GPCR mutations. Various degrees of inactive, overactive, or constitutively active receptors have been identified. These mutations often alter ligand binding, G protein coupling, receptor desensitization, and receptor recycling. The role
Embryonic Stem Cells as a Model for Studying Melanocyte Development
-producing polygonal cells forming epithelium in the retina, are directly induced from the neuroepithelium of the optic vesicle and are not affected by c-Kit W and Mgf Sl mutations. Another mutant, Edn3 ls , which lacks endothelin 3 (ET3), shows
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