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文献和实验Generation of Recombinant Adeno-Associated Virus
Adeno-associated virus (AAV) was discovered about 30 yr ago as a contaminant of adenovirus preparations. Since its discovery, researchers have described many unique characteristics of AAV biology that have made it attractive
Role of the Adeno-Associated Virus Capsid in Gene Transfer
Adeno-associated virus (AAV) is one of the most promising viral gene transfer vectors that has been shown to effect long-term gene expression and disease correction with low toxicity in animal models, and is well tolerated in human clinical
of laboratory stocks of adenovirus, little is known regarding their natural tissue tropism. Of the six isolates of AAV that have been identified to date in primates, only three (AAV2, 3, and 5) have been isolated from humans. Because AAV4 can infect human
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