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- 赛默飞（Thermo Fisher）
- PA137799
- 2025年07月14日
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文献和实验相关专题 T细胞被激活后，释放含穿孔素与颗粒酶的颗粒，在Ca2+的借助下，颗粒在靶细胞膜 上穿孔，进而颗粒酶(granzyme)进入靶细胞内，引起靶细胞DNA降解活动。对这种颗粒酶的研究也较多，已从人及鼠体内提取了10余种酶，认为起主要作用的是granzymea与granzymeB。 One mechanism used by cytotoxic T cells to kill tumor cells
Immunodetection of Granzyme B Tissue Distribution and Cellular Localisation
Investigation of Granzyme B (GrB) function and pathophysiology in both human settings and rodent models increasingly involve the use of indirect immunofluorescence imaging and fluorescence-activated cell sorting, which requires reliable GrB
Detection of Human and Mouse Granzyme B Activity in Cell Extracts
The serine protease granzyme B (GrB) is a key effector molecule in cell-mediated immunity, released by cytotoxic lymphocytes (CLs) to induce cell death in neoplastic or virus-infected cells. The ability to detect and measure GrB activity
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